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Inbreeding is bad; it causes sick and unstable dogs.
This goes with the idea (also erronous) than inbreeding doesn't occur in nature. Man's cultural taboos on inbreeding is largely behind all these myths. Inbreeding (linebreeding) & outcrossing are essentially neutral tools used to effect certain ends. It is certainly true that such a thing as inbreeding depression occurs when there is a loss of diversity amoung (some particular) genes in some individuals sometimes in some species, but there is also such a phenomena as outbreeding depression that occurs when you "mess with" a 'good' set of genes by introducing "new blood" into a breeding program. All this is demonstrated in wild as well as zoo populations as well as various domestic animal breeding programs. The point is you just cannot point & say "inbreeding is bad, outcrossing is good;" nature is never than simplistic. Bad breeding decisions often end in sick & unstable animals, but even the best breeding program has individuals who may fall ill. Along with this is the problem of confusing heterozygosity with heterosis (hybrid vigor). The latter is a first generation trait that occurs ONLY in the offspring of two individuals who are themselves from pure(in)bred strains; heterozygosity is a term that relates to whether a given individual has two or one kind of gene (alleles) at any given gene location (locus). The two terms don't even relate to the same level of discussion, and a hybrid is not necessarily "better." Having information on the actual animals in question is what is critical & no formula can replace that all important criteria. The results of any breeding demonstrate the skill (& luck) of the breeder. One of the most inbred lines of dogs in the world has the lowest breed incidence of hip dysplasia and the highest success rate as superior companion dogs--the seeing eye German Shepherd. Which is NOT to say "inbreeding is good;" the old breeder's saw about having to do an outcross every few generations is based on the observation that continuous inbreeding over generations can result in "inbreeding depression;" a phenomena, assumably, having to do with having too much similarity (homozygosity) among certain genes (such as immune genes). The point is one simply does not make breeding or buying choices based on single criteria or "cookbook" formulas--random outcrossing is as deadly as blindly linebreeding--smart breeders make careful selections every generation.